Checkpoint Kinase (Chk) Inhibitors

Chk1

Chk2

BUBR1

Checkpoint Kinase (Chk) Inhibitors, Agonists & Activators

Product Name	Chk1	Chk2	BUBR1	Purity
AZD-7762	Chk1, IC₅₀: 5 nM	Chk2, IC₅₀: 5 nM		99.94%
Prexasertib	Chk1, IC₅₀: <1 nM Chk1, Ki: 0.9 nM	Chk2, IC₅₀: 8 nM		98.74%
Rabusertib	Chk1, IC₅₀: 7 nM	Chk2, IC₅₀: 12000 nM		99.98%
BML-277		Chk2, IC₅₀: 15 nM		99.74%
MCL1020	Chk1, IC₅₀: 1.61 μM
CBP-501 acetate	Chk1, IC₅₀: 3.4 μM	Chk2, IC₅₀: 6.5 μM		99.75%
DHI1	Chk1
SCH900776	Chk1, IC₅₀: 3 nM	Chk2, IC₅₀: 1500 nM		99.97%
CCT245737	Chk1, IC₅₀: 1.3 nM	Chk2, IC₅₀: 2440 nM		99.24%
CHIR-124	Chk1, IC₅₀: 0.3 nM	Chk2, IC₅₀: 697.4 nM		99.05%
PF 477736	Chk1, Ki: 0.49 nM	Chk2, Ki: 47 nM		99.21%
CCT241533 hydrochloride	Chk1, IC₅₀: 245 nM	Chk2, IC₅₀: 3 nM Chk2, Ki: 1.16 nM		99.51%
PD 407824	Chk1, IC₅₀: 47 nM			99.00%
Prexasertib dihydrochloride	Chk1, IC₅₀: <1 nM Chk1, Ki: 0.9 nM	Chk2, IC₅₀: 8 nM		99.73%
CCT244747	Chk1, IC₅₀: 7.7 nM			99.46%
SB-218078	Chk1, IC₅₀: 15 nM			98.30%
Prexasertib dimesylate	Chk1, Ki: 0.9 nM Chk1, IC₅₀: <1 nM	Chk2, IC₅₀: 8 nM		98.90%
Lasmotinib		Chk2		98.97%
Indibulin			BUBR1	99.89%
GDC-0425	Chk1			99.60%
GDC-0575 dihydrochloride	Chk1, IC₅₀: 1.2 nM			99.32%
PV-1019		Chk2, IC₅₀: 24 nM		99.30%
SAR-020106	Chk1, IC₅₀: 13.3 nM			98.04%
GNE-900	Chk1, IC₅₀: 0.0011 μM	Chk2, IC₅₀: 1.5 μM		99.21%
MRT00033659	Chk1, IC₅₀: 0.23 μM			99.77%
ANI-7		Chk2		99.01%
CHK1-IN-3	Chk1, IC₅₀: 0.4 nM			99.79%
AZD-7762 hydrochloride	Chk1, IC₅₀: 5 nM	Chk2, IC₅₀: 5 nM		99.58%
Chk1-IN-5	Chk1			98.84%
CCT241533	Chk1, IC₅₀: 245 nM	Chk2, IC₅₀: 3 nM Chk2, Ki: 1.16 nM
Prexasertib Mesylate Hydrate	Chk1, Ki: 0.9 nM Chk1, IC₅₀: <1 nM	Chk2, IC₅₀: 8 nM
CBP-501	Chk1, IC₅₀: 3.4 μM	Chk2, IC₅₀: 6.5 μM		99.75%
Chk1-IN-6	Chk1			98.39%
VRX0466617	Chk1, IC₅₀: 120 nM Chk1, Ki: 11 nM			99.91%
Prexasertib mesylate	Chk1, Ki: 0.9 nM Chk1, IC₅₀: <1 nM	Chk2, IC₅₀: 8 nM
VER-00158411	Chk1, IC₅₀: 4.4 nM	Chk2, IC₅₀: 4.5 nM
CHK1-IN-4	Chk1
CHK1-IN-2	Chk1, IC₅₀: 6 nM
PD-321852	Chk1, IC₅₀: 5 nM
Chk2-IN-2		Chk2
CHK1-IN-11	Chk1
Chk2-IN-1	Chk1, IC₅₀: 220.4 nM	Chk2, IC₅₀: 13.5 nM
GDC0575 hydrochloride	Chk1, IC₅₀: 1.2 nM
CCT241533 dihydrochloride	Chk1, IC₅₀: 245 nM	Chk2, IC₅₀: 3 nM Chk2, Ki: 1.16 nM
CHK1-IN-9	Chk1, IC₅₀: 0.55 nM
CHK1-IN-13	Chk1, IC₅₀: 10-50 nM
Multi-kinase-IN-6	Chk1, IC₅₀: 0.15 μM
CHK1-IN-12	Chk1
PV1162	Chk1, IC₅₀: 59000 nM	Chk2, IC₅₀: 0.29 nM
Prexasertib lactate	Chk1, IC₅₀: <1 nM	Chk2, IC₅₀: 8 nM
CHK-IN-1	Chk1	Chk2

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